David H Hackos: search on Z-Library

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1

Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma

Reese, Rebecca M., Dourado, Michelle, Anderson, Keith, Warming, SÃ¸ren, Stark, Kimberly L., Balestrini, Alessia, Suto, Eric, Lee, Wyne, Riol-Blanco, Lorena, Shields, Shannon D., Hackos, David H.

Journal:

Scientific Reports

Year:

2020

Language:

english

File:

PDF, 1.01 MB

english, 2020

2

A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain

Wang, Tzu-Ming, Brown, Brandon M., Deng, Lunbin, Sellers, Benjamin D., Lupardus, Patrick J., Wallweber, Heidi J.A., Gustafson, Amy, Wong, Evera, Volgraf, Matthew, Schwarz, Jacob B., Hackos, David H.,

Journal:

Neuropharmacology

Year:

2017

Language:

english

File:

PDF, 22.32 MB

english, 2017

3

Correction to: Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel NaV1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy Volunteers

Rothenberg, Michael E., Tagen, Michael, Chang, Jae H., Boyce-Rustay, Janel, Friesenhahn, Michel, Hackos, David H., Hains, Avis, Sutherlin, Dan, Ward, Michael, Cho, William

Journal:

Clinical Drug Investigation

Year:

2019

Language:

english

File:

PDF, 499 KB

english, 2019

4

Structural Basis of Nav1.7 Inhibition by an Isoform-Selective Small Molecule Antagonist

Hackos, David H., Ahuja, Shivani, Mukund, Susmith, Deng, Lunbin, Khakh, Kuldip, Chang, Elaine, Young, Clint, Lin, Sophia, Johnson, J.P., Ortwine, Daniel F., Safina, Brian S., Sutherlin, Daniel P., Coh

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 66 KB

english, 2016

5

Diverse modes of NMDA receptor positive allosteric modulation: Mechanisms and consequences

Hackos, David H., Hanson, Jesse E.

Journal:

Neuropharmacology

Year:

2016

Language:

english

File:

PDF, 2.13 MB

english, 2016

6

Gating by Proteolysis: How Pannexin-1 is Maintained Closed by its C-Terminal Gating Peptide

Hackos, David H., Dourado, Michelle

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 57 KB

english, 2014

7

A Localized Interaction Surface for Voltage-Sensing Domains on the Pore Domain of a K+ Channel

Yingying Li-Smerin, David H Hackos, Kenton J Swartz

Journal:

Year:

2000

Language:

english

File:

PDF, 426 KB

english, 2000

8

Insensitivity to pain upon adult-onset deletion of Na v 1.7 or its blockade with selective inhibitors

Shields, Shannon D., Deng, Lunbin, Reese, Rebecca M., Dourado, Michelle, Tao, Janet, Foreman, Oded, Chang, Jae H., Hackos, David H.

Journal:

Journal of Neuroscience

Year:

2018

Language:

english

File:

PDF, 4.44 MB

english, 2018

9

TRPA1 as a drug target—promise and challenges

Chen, Jun, Hackos, David H.

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2015

Language:

english

File:

PDF, 595 KB

english, 2015

10

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

Chiang, Eugene Y., Li, Tianbo, Jeet, Surinder, Peng, Ivan, Zhang, Juan, Lee, Wyne P., DeVoss, Jason, Caplazi, Patrick, Chen, Jun, Warming, Søren, Hackos, David H., Mukund, Susmith, Koth, Christopher M

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 2.62 MB

english, 2017

11

AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist

Joel R Gever, Rothschild Soto, Robert A Henningsen, Renee S Martin, David H Hackos, Sandip Panicker, Werner Rubas, Ian B Oglesby, Michael P Dillon, Marcos E Milla, Geoffrey Burnstock, Anthony PDW Ford

Journal:

British Journal of Pharmacology

Year:

2010

Language:

english

File:

PDF, 660 KB

english, 2010

12

Identification of the molecular trigger for allosteric activation in glycogen phosphorylase

Browner, Michelle F., Hackos, David, Fletterick, Robert

Journal:

Natural Structural Biology

Year:

1994

File:

PDF, 779 KB

1994

13

Pannexin-1 Is Blocked by Its C-Terminus through a Delocalized Non-Specific Interaction Surface

Dourado, Michelle, Wong, Evera, Hackos, David H., Fotiadis, Dimitrios

Journal:

Year:

2014

Language:

english

File:

PDF, 5.77 MB

english, 2014

14

TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism

Chernov-Rogan, Tania, Gianti, Eleonora, Liu, Chang, Villemure, Elisia, Cridland, Andrew P., Hu, Xiaoyu, Ballini, Elisa, Lange, Wienke, Deisemann, Heike, Li, Tianbo, Ward, Stuart I., Hackos, David H.,

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

File:

PDF, 3.08 MB

2019

15

Structure- and ligand-based discovery of chromane arylsulfonamide Na v 1.7 inhibitors for the treatment of chronic pain

McKerrall, Steven John, Nguyen, Teresa, Lai, Kwong Wah, Bergeron, Philippe, Deng, Lunbin, DiPasquale, Antonio, Chang, Jae H., Chen, Jun, Chernov-Rogan, Tania, Hackos, David H., Maher, Jonathan, Ortwin

Journal:

Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 2.53 MB

2019

16

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

Hackos, David H., Lupardus, Patrick J., Grand, Teddy, Chen, Yelin, Wang, Tzu-Ming, Reynen, Paul, Gustafson, Amy, Wallweber, Heidi J.A., Volgraf, Matthew, Sellers, Benjamin D., Schwarz, Jacob B., Paole

Journal:

Year:

2016

Language:

english

File:

PDF, 3.53 MB

english, 2016

17

Computationally Discovered Potentiating Role of Glycans on NMDA Receptors

Sinitskiy, Anton V., Stanley, Nathaniel H., Hackos, David H., Hanson, Jesse E., Sellers, Benjamin D., Pande, Vijay S.

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 1.28 MB

english, 2017

18

Structural Basis of Pannexin Activation

Dourado, Michelle, Wong, Evera, Hackos, David

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 42 KB

english, 2013

19

Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors

Chernov-Rogan, Tania, Li, Tianbo, Lu, Gang, Verschoof, Henry, Khakh, Kuldip, Jones, Steven W., Beresini, Maureen H., Liu, Chang, Ortwine, Daniel F., McKerrall, Steven J., Hackos, David H., Sutherlin,

Journal:

Proceedings of the National Academy of Sciences

Year:

2018

Language:

english

File:

PDF, 1.37 MB

english, 2018

20

From The Lancet

Dourado, Michelle, Wong, Evera, Hackos, David

Journal:

Year:

1990

Language:

english

File:

PDF, 187 KB

english, 1990

21

α-Aryl pyrrolidine sulfonamides as TRPA1 antagonists

Verma, Vishal A., Shore, Daniel G.M., Chen, Huifen, Chen, Jun, Do, Steven, Hackos, David H., Kolesnikov, Aleks, Lyssikatos, Joseph P., Tay, Suzanne, Wang, Lan, Estrada, Anthony A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 1.78 MB

english, 2016

22

A Novel Membrane Potential Assay to Identify Nav1.7-Selective Blockers

Chernov-Rogan, Tania, Li, Tianbo, Verschoof, Henry, Khakh, Kuldip, Jones, Steven, McKerrall, Steve, Hackos, David H., Sutherlin, Dan, Cohen, Charles J., Chen, Jun

Journal:

Biophysical Journal

Year:

2017

Language:

english

File:

PDF, 50 KB

english, 2017

23

SCOTLAND.

Dourado, Michelle, Wong, Evera, Hackos, David

Journal:

Year:

1895

Language:

english

File:

PDF, 415 KB

english, 1895

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